Citation:
Pablo J Sanchís-Benlloch, Nocillado, Josephine , Ladisa, Claudia , Aizen, Joseph , Miller, Adam , Shpilman, Michal , Levavi-Sivan, Berta , Ventura, Tomer , and Elizur, Abigail . 2017. “In-Vitro And In-Vivo Biological Activity Of Recombinant Yellowtail Kingfish (Seriola Lalandi) Follicle Stimulating Hormone”. Gen Comp Endocrinol, 241, Pp. 41-49. doi:10.1016/j.ygcen.2016.03.001.
Abstract:
Biologically active recombinant yellowtail kingfish follicle stimulating hormone (rytkFsh) was produced in yeast Pichia pastoris and its biological activity was demonstrated by both in-vitro and in-vivo bioassays. Incubation of ovarian and testicular fragments with the recombinant hormone stimulated E and 11-KT secretion, respectively. In-vivo trial in immature female YTK resulted in a significant increase of plasma E levels and development of oocytes. In males at the early stages of puberty, advancement of spermatogenesis was observed, however plasma 11-KT levels were reduced when administered with rytkFsh.
